Learn about new treatments for ovarian cancer

Access innovative therapies that may be compatible with your ovarian cancer diagnosis

Today there are 36 clinical trials for ovarian cancer in Spain:

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Index

What is the treatment of ovarian cancer?

The therapeutic approach to ovarian cancer depends on the histological type and stage of diagnosis.

 

  • The treatment of ovarian cancer usually begins with surgery, which has two main goals: diagnosis and treatment. Due to the characteristics of this type of neoplasm, when its presence is suspected, it is necessary to intervene surgically to confirm the diagnosis and determine the type and extent of the tumor. This intervention, called optimal surgery, involves the surgical removal of the entire visible tumor, which is considered a treatment. Subsequently, the findings during surgery will determine whether it is necessary to complement the treatment with chemotherapy.

 

  • Chemotherapy is an adjuvant treatment to surgery in ovarian cancer. It can be administered beforehand to reduce the tumor size and after surgery if surgery is not feasible. It can also be combined with radiotherapy. It is used in early and advanced stages except in some very early-stage tumors, with favorable characteristics, where surgery alone may be sufficient.

 

  • Hormone therapy uses hormone-blocking drugs to fight cancer. It is occasionally used in epithelial ovarian cancer and, more frequently, in stromal ovarian tumors. It is an option for certain types of slow-growing ovarian cancers and may also be considered if the cancer recurs after initial treatment.

 

  • Radiation therapy uses X-rays or high-energy particles to destroy cancer cells. Although it is rarely the primary treatment for ovarian cancer, it can be helpful in treating areas where cancer has spread near the main tumor or in distant organs such as the brain or spinal cord.

 

In many cases, participating in a clinical trial may be the best therapeutic option. These studies have a significant impact on the treatment of the primary tumor, metastases and even the prevention of recurrences, such as PARP inhibitors that have been studied over the last decade to prevent the recurrence of the disease.

The clinical trial: the opportunity to receive a new treatment for ovarian cancer and its metastases

Clinical trials play a crucial role in clinical research, helping to increase ovarian cancer knowledge. Identifying new subtypes of this tumor could lead to the development of more precise drugs and the administration of the most appropriate treatment for each individual specific condition.

 

The patient who participates in a clinical trial, regardless of the stage of treatment, may also benefit from access to new therapies or increased follow-up by healthcare personnel.

New treatments for ovarian cancer under research

Research treatments for ovarian cancer offer patients the opportunity to access novel therapies with promising results, such as immune checkpoint inhibitors. These innovative biologic treatments weaken cancer cells and strengthen the immune system.

 

Immune checkpoint inhibitors block specific points in the immune system that cancer cells use to evade the immune response. By blocking these points, these therapies allow the immune system to attack the cancer and prevent its suppression more effectively.

 

Currently, immune checkpoint inhibitors, such as PARP inhibitors, are used to treat ovarian cancer. However, research continues to move toward more personalized ovarian cancer treatments for each specific patient.

H3: Clinical trials seeking to improve current treatment for ovarian cancer

Clinical trials are medical studies that evaluate new treatments for ovarian cancer. In these trials, they also investigate how to improve the efficacy of current treatments. One promising strategy is to combine different drugs to increase efficacy and improve patients’ quality of life. For example, chemotherapy can be administered after surgery with immune checkpoint inhibitors.

Clinical trials looking for your best treatment for ovarian cancer

Some trials do not seek to compare one drug with another but to personalize treatment for patients as much as possible. Each person is unique. Each cancer is unique. Even each metastasis is unique. Standard treatments are applied because, in general, they are the ones that work best for most patients. However, as treatments are more personalized, the higher the survival rate and patients achieve a better quality.

References

American Cancer Society, 2023: Cirugía para el cáncer de ovario

Mayo Clinic, 2023: Cáncer de ovario

Centros para el Control y la Prevención de Enfermedades (CDC), 2023: ¿Cómo se trata el cáncer de ovario?

Instituto Nacional del Cáncer, 2023: SIRPa-Fc-CD40L fusion protein SL-172154

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